Coxiella burnetii lipopolysaccharide blocks p38α-MAPK activation through the disruption of TLR-2 and TLR-4 association
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Coxiella burnetii lipopolysaccharide blocks p38α-MAPK activation through the disruption of TLR-2 and TLR-4 association
To survive in macrophages, Coxiella burnetii hijacks the activation pathway of macrophages. Recently, we have demonstrated that C. burnetii, via its lipopolysaccharide (LPS), avoids the activation of p38α-MAPK through an antagonistic engagement of Toll-like receptor (TLR)-4. We investigated the fine-tuned mechanism leading to the absence of activation of the p38α-MAPK despite TLR-4 engagement. ...
متن کاملبررسی تأثیر ابتلا به پریودنتیت مزمن بر میزان بیان ژن TLR-2 و TLR-4 در بافت لثه ای
مقدمه: در عفونتهای پریودنتال پیش نیاز شروع پاسخهای میزبان، شناخت پاتوژنها توسط سیستم ایمنی میزبان میباشد. خانواده رسپتورهای Toll-like (TLRs)، مسئول شناسایی ساختارهای حفظ شده میکروبیال نظیر لیپوپلی ساکارید (LPS) باکتریها میباشند و مسیرهای سیگنال دهنده را که در نهایت منجر به پاسخهای ایمنی میشود، فعال میکنند. هدف از مطالعة حاضر، ارزیابی مقایسه میزان بروز TLR-2 و TLR-4 توسط تکنیک Real-...
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متن کاملBacterial lipopolysaccharide activates NF-kappaB through toll-like receptor 4 (TLR-4) in cultured human dermal endothelial cells. Differential expression of TLR-4 and TLR-2 in endothelial cells.
A missense mutation in the cytoplasmic domain of the Toll-like receptor-4 (TLR-4) has been identified as the defect responsible for lipopolysaccharide (LPS) hyporesponsiveness in C3H/HeJ mice. TLR-4 and TLR-2 have recently been implicated in LPS signaling in studies where these receptors were overexpressed in LPS non-responsive 293 human embryonic kidney cells. However, the signaling role of TL...
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ژورنال
عنوان ژورنال: Frontiers in Cellular and Infection Microbiology
سال: 2015
ISSN: 2235-2988
DOI: 10.3389/fcimb.2014.00182